Neuropsychiatric Symptoms in Korean Patients with Alzheimers Disease: Exploratory Factor Analysis and Confirmatory Factor Analysis of the Neuropsychiatric Inventory

Dement Geriatr Cogn Disord 2010;29:8287 (DOI:10.1159/000264629)

Mitochondrial DNA haplogroups in early-onset Alzheimer's disease and frontotemporal lobar degeneration

Background:Mitochondrial dysfunction, oxidative damage as well as a accumulation of somatic mutations in mitochondrial DNA (mtDNA) have been compared with certain neurodegenerative disorders. Previous studies have also provided controversial formula on a organisation of mtDNA haplogroups with ionization to Alzheimer's mildew (AD), though possible relations between mtDNA as well as frontotemporal lobar lapse (FTLD) have been reduction frequently studied.Methods:We analysed a role of mtDNA as well as a upkeep enzymes in 128 early-onset AD (eoAD) as well as in 66 FTLD cases. Patients as well as 99 controls were collected from a defined segment of Finland, which of Northern Ostrobothnia, for a determination of mtDNA haplogroups as well as a analysis of two common mtDNA mutations (m.3243A>G, m.8344A>G). In addition, screening was performed for 5 common POLG1 mutations (T251I, A467T, P587L, W748S as well as Y955C) as well as all a coding exons of a PEO1 as well as ANT1 genes were screened for mutations.Results:The magnitude of haplogroup cluster IWX was 2.3 fold higher among a FTLD cases than in a controls (OR 2.69, 95% CI 1.09-6.65, p=0.028). The magnitude of mtDNA haplogroups or clusters did not talk about between a eoAD cases as well as controls. The two mtDNA mutations as well as 5 POLG1 mutations were absent in a eoAD as well as FTLD patients. No pathogenic mutations were found in a PEO1 or ANT1 genes.Conclusions:We conclude which a haplogroup cluster IWX was compared with FTLD in the cohort. Further studies in other ethnically graphic cohorts are needed to explain a grant of mtDNA haplogroups to FTLD as well as AD.

Diabetes Is Associated with Increased Rate of Cognitive Decline in Questionably Demented Elderly

Dement Geriatr Cogn Disord 2010;29:6874 (DOI:10.1159/000265552)