GSK3 and p53 - is there a link in Alzheimer's disease?

Background:Recent justification suggests which glycogen synthase kinase-3beta (GSK3beta) is implicated in both occasionally as well as familial forms of Alzheimer's disease. The transcription factor, p53 additionally plays a purpose as well as has been related to an increase in tau hyperphosphorylation nonetheless a outcome is indirect. There is additionally justification which GSK3beta as well as p53 correlate as well as which a wake up of both proteins is increasing as a result of this interaction. Under normal mobile conditions, p53 is kept during low levels by Mdm2 though when cells have been stressed, p53 is stabilised as well as might then correlate with GSK3beta. We propose which this interaction has an important contribution to mobile outcomes as well as to test this supposition we developed a stochastic simulation model.Results:The indication predicts which high levels of DNA repairs leads to increasing wake up of p53 as well as GSK3beta as well as low levels of assembly though if DNA repairs is repaired, a aggregates have been in a future cleared. The indication additionally shows which over prolonged periods of time, aggregates might begin to form due to stochastic events heading to increasing levels of ROS as well as shop-worn DNA. This is followed by increasing wake up of p53 as well as GSK3beta as well as a vicious cycle ensues.Conclusions:Since p53 as well as GSK3beta have been both involved in a apoptotic pathway, as well as GSK3beta overactivity leads to increasing levels of plaques as well as tangles, our indication might explain a couple in between protein assembly as well as neuronal loss in neurodegeneration.